Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → HCID 68491790, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| 반응물 | 4-Fluoro-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone | HCID 68493841 | — |
| 반응물 | HCID 178444656 | HCID 178444656 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 68491790 | HCID 68491790 | 40% |
| 생성물 | 1-(1-Methyl-1-phenylethyl)-3-fluoro-6-iodophtalimide | HCID 131728234 | 14% |
반응 단계
In a similar manner to Step 3 of Example 16, 4-fluoro-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (2.06 g, 7.22 mmol) was dissolved in THF (80 mL), and the solution was treated with TMEDA (2.40 mL, 15.9 mmol), sec-butyllithium-hexane solution (0.99 mol/L, 16.0 mL, 15.9 mmol) and iodine (2.20 g, 8.66 mmol), followed by purification by flash column chromatography (chloroform/methanol=100/0, 85/15) to obtain 4-fluoro-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (1.19 g, yield 40%) and 1-(1-methyl-1-phenylethyl)-3-fluoro-6-iodophtalimide (425 mg, yield 14%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-08104d4147f74fd5967f2101c4f10757 |
| 출처 메모 | uspto-grants-2010_06 |