Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 4-Methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| 반응물 | 4-Methoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone | HCID 68488636 | — |
| 반응물 | HCID 178444656 | HCID 178444656 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone | HCID 68491173 | 77% |
반응 단계
In a similar manner to Step 3 of Example 16, 4-methoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (3.55 g, 11.9 mmol) was dissolved in THF (140 mL), and the solution was treated with TMEDA (4.00 mL, 26.2 mmol), sec-butyllithium-hexane solution (0.99 mol/L, 26.4 mL, 26.2 mmol) and iodine (3.62 g, 14.3 mmol), followed by purification by flash column chromatography (hexane/ethyl acetate=9/1, 7/3) to obtain 4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (3.88 g, yield 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-81f75ec20d134ed9b2b858fa950481b5 |
| 출처 메모 | uspto-grants-2010_06 |