Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → HCID 68491791, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| 반응물 | 4-Phenoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone | HCID 68488471 | — |
| 반응물 | HCID 178444656 | HCID 178444656 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 68491791 | HCID 68491791 | 75% |
반응 단계
In a similar manner to Step 3 of Example 16, 4-phenoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (700 mg, 1.95 mmol) was dissolved in THF (28 mL), and the solution was treated with TMEDA (0.94 mL, 6.2 mmol), sec-butyllithium-hexane solution (1.01 mol/L, 6.20 mL, 6.24 mmol) and iodine (594 mg, 2.34 mmol), followed by purification by flash column chromatography (chloroform/methanol=100/0, 99/1) to obtain 4-phenoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (708 mg, yield 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-9631ac4d6b004664a4b556521edc54fa |
| 출처 메모 | uspto-grants-2010_06 |