Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Acetylpyridine → 5-(Pyridin-3-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Acetylpyridine | HCID 9589 | — |
| 반응물 | 1,3-Butanedione, 4,4,4-trifluoro-1-(3-pyridinyl)- | HCID 68495 | — |
| 반응물 | HCID 178510443 | HCID 178510443 | — |
| 생성물 | 5-(Pyridin-3-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 46949670 | 16% |
반응 단계
Reaction of 1-pyridin-3-yl-4,4,4-trifluoro-butane-1,3-dione (217 mg, 1.0 mmol), prepared from commercially available 3-acetylpyridine according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as an off-white solid (45 mg, 16%). MS (ISP) 290.2 [(M+H)+]; mp 193° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07514443B2 |
| 출처 데이터셋 | uspto-grants-2009_04 |
| ORD ID | ord-9ee1b95215684ea1905bf436f94e9a47 |
| 출처 메모 | uspto-grants-2009_04 |