Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 2,5-Dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzylmaleimide | HCID 74204 | — |
| 반응물 | N-Benzylglycine Hydrochloride | HCID 2756624 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2,5-Dibenzyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione | HCID 21867682 | — |
반응 단계
A mixture of paraformaldehyde (3.37 g), N-benzylmaleimide (2.80 g) and N-benzylglycine hydrochloride (3.02 g) in toluene (100 mL) was heated to reflux with azeotropic removal of water for 16 hours. The mixture was cooled to room temperature, filtered and concentrated in vacuo. The residue was purified by flash chromatography (20% EtOAc/hexane) to afford the title compound 1 as a low melting white solid (3.60 g, 75%). LCMS: Rf: 2.616 min, M+H+: 321.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07435830B2 |
| 출처 데이터셋 | uspto-grants-2008_10 |
| ORD ID | ord-a83cfb5c8fcb47b0b96e87cdd29a9bc2 |
| 출처 메모 | uspto-grants-2008_10 |