4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline → (R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine

참여 물질

역할	이름	HCID	투입량
반응물	4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline	HCID 44627476	—
반응물	(2R)-8-chloro-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepine	HCID 57512880	—
시약	Cesium carbonate	HCID 10796	—
촉매	2-(Dicyclohexylphosphino)biphenyl	HCID 2734216	—
촉매	Palladium (II) acetate	HCID 4144353	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	(R)-4-Methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine	HCID 49819370	0%

반응 조건

온도	100 °C

반응 단계

A solution of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.00 mg, 0.02 mmol) and 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (3.17 mg, 0.02 mmol) in DME (.5 mL) was added via a syringe to a capped microwave vial containing PALLADIUM(II) ACETATE (0.409 mg, 1.82 µmol), 2-(DICYCLOHEXYLPHOSPHINO)BIPHENYL (0.638 mg, 1.82 µmol), CESIUM CARBONATE (8.89 mg, 0.03 mmol) and KI (1.511 mg, 9.10 µmol) under an argon atmosphere. The resulting mixture was heated to 100°C in a microwavwe apparatus for 1 h and analyzed by LCMS. No product.

출처 및 근거

출처 데이터셋	750 AstraZeneca ELN dataset
ORD ID	ord-7b17e577dfcd4694a98108d8e01246cd
출처 메모	750 AstraZeneca ELN dataset