Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 216368생성일: 2026년 10월 24일
Hexamethylditin → 1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]-2-(4-isothiazol-5-ylphenyl)propan-2-ol
https://huagongshe.com/ko/reaction/216368
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hexamethylditin | HCID 6327618 | — |
| 반응물 | 5-Bromo-1,2-thiazole | HCID 12631174 | — |
| 반응물 | 2-(4-bromophenyl)-1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]propan-2-ol | HCID 59161994 | — |
| 촉매 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]-2-(4-isothiazol-5-ylphenyl)propan-2-ol | HCID 68667735 | — |
반응 단계
Palladium tetrakis(triphenylphosphine) (39 mg, 0.03 mmol) was added to a degassed, ambient temperature solution of 5-bromoisothiazole (55 mg, 0.34 mmol), 2-(4-bromophenyl)-1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]propan-2-ol (200 mg, 0.34 mmol) and hexamethylditin (110 mg, 0.34 mmol) in 1,4-dioxane (15 mL). After stirring at 90° C. for 16 h, the reaction mixture was diluted with water and extracted with ethyl acetate and methylene chloride. The combined organic extracts were concentrated in vacuo. Chromatography over silica eluting with 0-50% ethyl acetate/hexane afforded 1-[4-(2,2-dimethylpropyl)-1-trityl-1H-imidazol-2-yl]-2-(4-isothiazol-5-ylphenyl)propan-2-ol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08193228B2 |
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| 출처 데이터셋 | uspto-grants-2012_06 |
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| ORD ID | ord-237fa4327f57447ba8d9f978e23a8761 |
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| 출처 메모 | uspto-grants-2012_06 |
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