Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-bromo-2-(bromomethyl)benzoate → 5-Bromo-2-methyl-2,3-dihydro-1H-isoindol-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-bromo-2-(bromomethyl)benzoate | HCID 22031079 | — |
| 반응물 | Monomethylamine methanol | HCID 57454252 | — |
| 생성물 | 5-Bromo-2-methyl-2,3-dihydro-1H-isoindol-1-one | HCID 23158169 | — |
반응 단계
A solution of methyl 4-bromo-2-(bromomethyl)benzoate (410 mmol) in MeNH2/MeOH (1500 mL) was heated to reflux and stirred for 18 h. The reaction mixture was concentrated and the residue was purified by chromatography on silica eluting with petroleum ether/ethyl acetate (6:1 to 3:1) to afford the sub-titled compound (48.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08193239B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-1ee68ce3184b4df29e51592a33f34921 |
| 출처 메모 | uspto-grants-2012_06 |