Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butylsulfinamide, (S)-(-)- → (S)-N-(5-bromo-6-(((tert-butylsulfinyl)imino)methyl)pyridin-2-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| 반응물 | N-(5-Bromo-6-formyl-2-pyridinyl)acetamide | HCID 90280237 | — |
| 촉매 | Copper Sulfate | HCID 24462 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-N-(5-bromo-6-(((tert-butylsulfinyl)imino)methyl)pyridin-2-yl)acetamide | HCID 90280385 | — |
반응 단계
Copper(II) sulfate (anhydrous 2.8 g, 17.2 mmol) was added to a solution of N-(5-bromo-6-formylpyridin-2-yl)acetamide (crude material, assume 8.6 mmol) and (S)-2-methylpropane-2-sulfinamide (1.2 g, 9.4 mmol) in DCM (30 ml). The suspension was stirred overnight at room temperature. The reaction was filtered and washed with DCM (3×20 ml). The filtrate was concentrated. The crude product was purified by flash column (30% EtOAc/Hexanes). MS (m/z) 346.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09050344B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-32e67f315d79418688dd525d9f8d0186 |
| 출처 메모 | uspto-grants-2015_06 |