참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| 반응물 | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Diphenylmethyl)-3-(2-thienylmethoxy)azetidine | HCID 67154602 | — |
반응 단계
To a solution of 1-diphenylmethylazetidin-3-ol (359 mg, 1.5 mmol) in DMF (1 mL) at 0° C. under nitrogen was added NaH (60% in oil, 66 mg, 1.65 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with 2-(chloromethyl)thiophene (464 mg, 3.5 mmol; which may be prepared as described in Step 1) dissolved in DMF (2 mL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09051321B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_06 |
|---|
| ORD ID | ord-2727df192e7b4ea0bfd48e78ab5e4410 |
|---|
| 출처 메모 | uspto-grants-2015_06 |
|---|
