Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Pyrimidin-2-yl)propan-2-one → (E)-N-(1-benzhydrylazetidin-3-yl)oxy-1-pyrimidin-2-ylpropan-2-imine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Pyrimidin-2-yl)propan-2-one | HCID 12656663 | — |
| 반응물 | 3-(Aminooxy)-1-(diphenylmethyl)azetidine | HCID 67154688 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (E)-N-(1-benzhydrylazetidin-3-yl)oxy-1-pyrimidin-2-ylpropan-2-imine | HCID 88941950 | 100.7% |
반응 단계
A solution of 1-pyrimidin-2-ylacetone (27 mg, 0.2 mmol; which may be prepared as described in Step 1) and 3-(aminooxy)-1-(diphenylmethyl)azetidine (51 mg, 0.2 mmol; which may be prepared as described in Step 3) in ethanol (2 mL) under nitrogen was stirred at 80° C. overnight. The crude mixture was concentrated to dryness to give the title compound (75 mg, quantitative) as a brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09051321B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-00e2ed0eeca3486fad70fadbefde5f72 |
| 출처 메모 | uspto-grants-2015_06 |