Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Phthalic Anhydride | HCID 6811 | — |
| 반응물 | tert-Butyl carbazate | HCID 70091 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide | HCID 801162 | 104.1% |
반응 단계
250 g of tert-butyl hydrazinecarboxylate was added to toluene (3 L) solution of 280 g of phthalic anhydride. Using a Dean-Stark water separator, the reaction mixture was heated under reflux for 3 hours. This was cooled to room temperature, the formed solid was taken out through filtration to obtain 516 g of crude tert-butyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)carbamate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198281B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-10d819d63d1f48a2b6875ffefe059d2d |
| 출처 메모 | uspto-grants-2012_06 |