Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Morpholin-4-yl)propanoic acid → (3aR,4S,7aR)-4-(3-morpholin-4-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Morpholin-4-yl)propanoic acid | HCID 410813 | — |
| 반응물 | (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester | HCID 68276168 | — |
| 생성물 | (3aR,4S,7aR)-4-(3-morpholin-4-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester | HCID 60142172 | — |
반응 단계
Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and 3-morpholin-4-yl-propionic acid to yield (3aR,4S,7aR)-4-(3-morpholin-4-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H]=296 (ester elimination ion); RT=4.088 min; LC-MS Method III
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09067881B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-ae0c7bffba2b45b6a176912e70e34509 |
| 출처 메모 | uspto-grants-2015_06 |