참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl Acrylate | HCID 7294 | — |
| 반응물 | (Nitromethyl)cyclohexane | HCID 220634 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 용매 | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| 생성물 | Rac-4-cyclohexyl-4-nitro-butyric acid methyl ester | HCID 59438496 | — |
반응 단계
To a solution of 3.18 g (22.2 mmol) nitromethyl-cyclohexane (CAS: 2625-30-1) in 1 ml tert-butanol and 0.12 ml 35% benzyltrimethylammonium hydroxide in methanol warmed to 40° C. were added 1.99 ml (22.2 mmol) methyl acrylate. The yellow mixture was stirred at 40° C. for 2 hours then diluted with water and extracted with ethyl acetate. The combined extracts were washed with brine, dried over sodium sulfate, filtered and evaporated. The title compound was obtained in as slightly yellow oil: MS (EI): 198 (M.+−MeO), 183 (M.+−NO2), 151 (M−(MeO+NO2+H)).+ (100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09067911B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_06 |
|---|
| ORD ID | ord-96e1426b49f64e8294b979625162717f |
|---|
| 출처 메모 | uspto-grants-2015_06 |
|---|
