Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonyl chloride → 3-(4-Bromophenyl)propyl methanesulphonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-(4-Bromophenyl)propan-1-ol | HCID 10560614 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(4-Bromophenyl)propyl methanesulphonate | HCID 19688466 | 98.9% |
반응 단계
To a stirred solution of 3-(4-Bromophenyl)propan-1-ol (500 g, 2.30 mol) and diisopropylethylamine (312 g, 2.40 mol) in anhydrous dichloromethane (4 L) at 0˜5° C. was added dropwise methanesulphonyl chloride (280 g, 2.40 mol) slowly. After addition, the reaction mixture was stirred for 1 hour at 0˜5° C. The reaction mixture was washed with brine (1 L) twice. The organic phase was concentrated in vacuo to afford the subtitle compound (i) (667 g). HPLC Retention Time=1.353 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198285B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-1f92c5e26ddd484ea11e7af9ea1e0168 |
| 출처 메모 | uspto-grants-2012_06 |