Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,3-Difluoropyrrolidine hydrochloride → 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,3-Difluoropyrrolidine hydrochloride | HCID 24903482 | — |
| 반응물 | HCID 71558051 | HCID 71558051 | — |
| 반응물 | 5-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 86683299 | — |
| 생성물 | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558053 | — |
반응 단계
In analogy to the procedure described for the synthesis of 4-(5-tert-butyl-3-(4-methoxy benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)morpholine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 3,3-difluoropyrrolidine hydrochloride and isolated as white solid (5.1 mg, 30%). MS (m/e): 405.4 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09067943B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-eceb14eddaca4dcf98c473af94d3ad3d |
| 출처 메모 | uspto-grants-2015_06 |