Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,3-diphenylpropanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,3-diphenylpropanoate | HCID 68705735 | — |
| 용매 | NaOH MeOH DMSO | HCID 86640187 | — |
| 생성물 | 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,3-diphenylpropanoic acid | HCID 59251185 | 73% |
반응 단계
Methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,3-diphenylpropanoate (346 mg, 0.77 mmol) was heated to 100 C overnight in a mixture of 2 M NaOH/MeOH/DMSO (1:1:1). The next day, the reaction was cooled, acidified to pH 5 with HCl and extracted 2× EtOAc. The organic layers were washed with water×2, dried over MgSO4, filtered, concentrated in vacuo, and purified by HPLC to give 245 mg (73% yield) of acid 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,3-diphenylpropanoic acid. MS found: (M+H)+=389.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198311B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-4a1a10f9e279425992082fe44cfe6f17 |
| 출처 메모 | uspto-grants-2012_06 |