Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Bistrifluoroacetoxyiodobenzene | HCID 12041285 | — |
| 반응물 | N-Methoxy-N-methyl-1H-indazole-3-carboxamide | HCID 16036867 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide | HCID 20580738 | 72% |
반응 단계
To a solution of N-methoxy-N-methyl-1H-indazole-3-carboxamide (12.4 g, 60.42 mmol) in CH2Cl2 (200 mL) was added bis(trifluoroacetoxy)iodobenzene (28.78 g, 66.74 mmol), followed by dropwise addition of iodine (9.22 g, 36.33 mmol) in CH2Cl2 at rt. The reaction was stirred overnight, after which 300 mL saturated NaHSO3 was added and a solid began to precipitate, which was then filtered. The filtrate was concentrated and triturated with a small amount of CH2Cl2. The combined solids were dried to give 5-iodo-N-methoxy-N-methyl-1H-indazole-3-carboxamide (14.4 g, 72%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198456B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-bf0c526919e04f2bb8dbe14fc2f2e7db |
| 출처 메모 | uspto-grants-2012_06 |