Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2R)-1-aminopropan-2-ol → 3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropyl]isonicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2R)-1-aminopropan-2-ol | HCID 439938 | — |
| 반응물 | 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid | HCID 59026791 | — |
| 생성물 | 3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropyl]isonicotinamide | HCID 57649621 | — |
반응 단계
3-[(2-fluoro-4-iodophenyl)amino]-N-[(2S)-2-hydroxypropyl]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.3 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.4 mmol of 2-(R)-hydroxypropylamine. LC/MS [8.40 min; 416 (M+1)]
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198457B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-40d67f480ca24c2692e4ba1d6717d431 |
| 출처 메모 | uspto-grants-2012_06 |