Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-((3-Bromofuran-2-yl)methyl)morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 3-Bromo-2-furaldehyde | HCID 3367271 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-((3-Bromofuran-2-yl)methyl)morpholine | HCID 71065869 | 95.5% |
반응 단계
To a solution of 3-bromofuran-2-carbaldehyde (500 mg, 2.85 mmol) and morpholine (0.5 mL, 5.71 mmol) in CH2Cl2 (10 mL) was added sodium triacetoxyborohydride (1.2 g, 5.71 mmol). The mixture was stirred at room temperature for 12 hours. The reaction mixture was diluted with EtOAc (100 mL). The organic phase was washed with aqueous NaHCO3 and brine then dried (MgSO4), filtered and concentrated to dryness. The residue was purified by column chromatography (silica, 0-10% MeOH in CH2Cl2) to afford the sub-title compound (670 mg, 89%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08324264B1 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-8401e681973a4acfa7612176c9813769 |
| 출처 메모 | uspto-grants-2012_12 |