Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → HCID 59190377, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| 반응물 | HCID 59190391 | HCID 59190391 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 59190377 | HCID 59190377 | 30.4% |
반응 단계
To a solution of (S)-1-(4-bromo-phenyl)-ethyl amine (3.58 g, 0.018 mol) in dry CH3CN (350 mL) was added 3-((1S)-1-(4-bromophenyl)ethyl)-7-(2-methylallyl)-7-phenyl-1,3-oxazepan-2-one (4.2 g, 0.018 mol), KI (3.19 g, 0.019 mol), and K2CO3 (3.73 g, 0.027 mol). The mixture was stirred at reflux overnight, filtered, and concentrated to give the crude product, which was purified by column chromatography to give 7-((1S)-1-(4-bromophenyl)ethylamino)-2-methyl-4-phenylhept-1-en-4-ol (2.2 g, 30%) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202857B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-866cf1e4c35044579d28f1e177a45e92 |
| 출처 메모 | uspto-grants-2012_06 |