Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (R)-2-(5-bromo-4-cyano-2-fluorophenylamino)-3-cyclopropylpropanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Bromo-4,5-difluorobenzonitrile | HCID 19261277 | — |
| 반응물 | (R)-2-amino-3-cyclopropylpropanamide | HCID 59001002 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (R)-2-(5-bromo-4-cyano-2-fluorophenylamino)-3-cyclopropylpropanamide | HCID 67508107 | 99.9% |
반응 단계
A solution of 2-bromo-4,5-difluorobenzonitrile (218 mg, 1.00 mmol), (R)-2-amino-3-cyclopropylpropanamide (188 mg, 1.14 mmol) and DIEA (0.600 mL, 3.45 mmol) in DMSO (3 mL) was stirred at 120 C for 18 h. Water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2SO4, concentrated in vacuo to give (R)-2-(5-bromo-4-cyano-2-fluorophenylamino)-3-cyclopropylpropanamide (326 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09359375B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-6c434196f0eb473ca1c2169d53ac448e |
| 출처 메모 | uspto-grants-2016_06 |