Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 6-(1-Carbamoylcyclopentylamino)-5-fluoro-2-(quinolin-3-ylamino)nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrogen Peroxide | HCID 784 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-(5-Cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide | HCID 67509781 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 6-(1-Carbamoylcyclopentylamino)-5-fluoro-2-(quinolin-3-ylamino)nicotinamide | HCID 67515134 | — |
반응 단계
To a solution of crude 1-(5-cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide in EtOH (2 mL) and DMSO (1 mL), aq. 1N NaOH (1 mL) and aq. H2O2 (50%, 1 mL) were added. The mixture was stirred for 1 h. HOAc (0.5 mL) was added. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound (41 mg). MS 409.4 (M+H); UV 224.1, 243.7, 302.6, 324.8 nm; t 0.495 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09359375B2 |
| 출처 데이터셋 | uspto-grants-2016_06 |
| ORD ID | ord-8967b6529fa146fbad9f62cb21b85d70 |
| 출처 메모 | uspto-grants-2016_06 |