참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Piperazine Dihydrochloride | HCID 8893 | — |
| 반응물 | 3-Bromo-2-chloropyridine | HCID 693324 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(3-Bromopyridin-2-yl)piperazine | HCID 13298529 | 71% |
반응 단계
Add 3-bromo-2-chloro-pyridine (10.08 g, 52.4 mmol) to piperazine (45 g) and piperazine dihydrochloride (83.4 g). Heat the mixture to 190° C. with stirring for one hr. Allow the mixture to cool to about 80° C. then pour the material into water and extract 5 times with DCM. Dry the solution (sodium sulfate), filter and concentrate. Purify using silica gel chromatography, eluting with 15:85 methanol (with 2 M ammonia): DCM to give 1-(3-bromo-pyridin-2-yl)-piperazine as a white solid (8.98 g, 71%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08202873B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-db0422694fed4110a18c86f5a7031188 |
|---|
| 출처 메모 | uspto-grants-2012_06 |
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