Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Hydroxy-1-tetralone → oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Hydroxy-1-tetralone | HCID 119921 | — |
| 반응물 | (-)-Epichlorohydrin | HCID 2734062 | — |
| 생성물 | oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone | HCID 86748747 | — |
반응 단계
reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)-epichlorhydrine, in an aprotic solvent in the presence of a strong base at a temperature of over 90° C., to give the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone with an optical purity greater than 95%, and then,
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05426227 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-7d47044e2ac44991bb2f6c1fec64c091 |
| 출처 메모 | uspto-grants-1995_06 |