Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Fluorothiophenol | HCID 67789 | — |
| 반응물 | Methyl 2-hydroxy-2-methyl-3-(4-fluorophenylthio)-propionate | HCID 21966928 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid | HCID 9813367 | — |
반응 단계
The methyl 2-methyl-oxirane-carboxylate of formula (1), which was obtained by epoxidation, was reacted with 4-fluorothiophenol [formula (2)] in the presence of sodium hydride under the conditions listed in Scheme-2. The obtained methyl 2-hydroxy-2-methyl-3-(4-fluorophenylthio)-propionate of formula (3) was hydrolyzed with potassium hydroxide in aqueous ethanol over a period of 22 hours to yield the 2-hydroxy-2-methyl-3-(4-fluorophenylthio)-propionic acid of formula (4), which was converted into acid chloride of formula (5) with thionyl chloride in dimethyl acetamide at −15° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07102026B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-c604cc732ca64c99b9765e91bfb0a4be |
| 출처 메모 | uspto-grants-2006_09 |