Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Methyl 3-phenoxybenzeneacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Trimethylamine | HCID 1146 | — |
| 반응물 | 3-Phenoxyphenylacetic acid | HCID 141749 | — |
| 반응물 | Methyl 2-aminopentanoate | HCID 533890 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 3-phenoxybenzeneacetate | HCID 14815950 | 131.8% |
반응 단계
A mixture of (3-Phenoxy-phenyl)-acetic acid (10.00 g, 0.0438 mol), 2-amino-pentanoic acid methyl ester (7.34 g, 0.0438 mol.), HBOT (6.20 g, 0.046 mol), EDC. HCl (12.59 g, 0.067 mol) and a trimethylamine (30.45 ml, 0.22 mol) in methylene chloride (150 ml) was stirred at room temperature overnight. The mixture was quenched with water and extracted with methylene chloride. The organic layer was washed with 1N HCl, then brine, dried over sodium sulfate and the solvent was removed at reduced pressure to provide 13.99 g of (3-phenoxy-phenyl)-acetic acid methyl ester as a thick oil, LC-MS M+1=342.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07112599B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-d25034b59c1541e0ae6e9262dd1aea8f |
| 출처 메모 | uspto-grants-2006_09 |