Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 4-Octyloxy-benzoic acid 4-(4-hydroxy-cyclohexyl)-phenyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | 4-(Octyloxy)benzoic acid | HCID 17231 | — |
| 반응물 | Methyl 2-hydroxy-4-octyloxybenzoate | HCID 11536459 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | 4-Octyloxy-benzoic acid 4-(4-hydroxy-cyclohexyl)-phenyl ester | HCID 69307345 | 27% |
반응 단계
10 g (0.052 mol) of 4-(4-Hydroxy-cyclohexyl)-phenol obtained in Step 1 of the synthesis of the compound 27 and 13.02 g (0.052 mol) of 4-Octyloxy-benzoic acid are dissolved in 120 mL of anhydrous THF. 0.65 g (0.0052 mol) of DMAP, then 6.56 g (0.052 mol) of DIC are added. The mixture is stirred at room temperature overnight. The solvent is distilled off and then the resulting product is purified by column chromatography on silica gel using mixture of hexane and ethyl acetate (70:30) as eluent and recrystallised from ethanol to give a pure product as a white solid (6 g, 27% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07416682B2 |
| 출처 데이터셋 | uspto-grants-2008_08 |
| ORD ID | ord-6785549646bf4f4087b04dfa766f68f1 |
| 출처 메모 | uspto-grants-2008_08 |