1,1'-Carbonyldiimidazole → 3-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-1-methyl-1-(2-methyl-quinolin-4-yl)-urea

https://huagongshe.com/ko/reaction/2223713

참여 물질

역할	이름	HCID	투입량
반응물	1,1'-Carbonyldiimidazole	HCID 68263	—
반응물	Sodium bis(trimethylsilyl)amide	HCID 2724254	—
반응물	2-(4-Benzylpiperidin-1-yl)ethan-1-amine	HCID 2779831	—
반응물	N,2-dimethylquinolin-4-amine	HCID 13042979	—
용매	Dimethyl Sulfoxide	HCID 679	—
용매	Water	HCID 962	—
생성물	3-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-1-methyl-1-(2-methyl-quinolin-4-yl)-urea	HCID 17956492	—

반응 조건

온도	20 °C

반응 단계

To a stirred solution of CDI (178 mg, 1.1 mmol) in DMSO (5 mL) is added a solution of 2-(4-benzyl-piperidin-1-yl)-ethylamine (218 mg, 1 mmol) in DMSO (1 mL). The reaction mixture is stirred at 20° C. for 3 h. Methyl-(2-methyl-quinolin-4-yl)-amine (173 mg, 1 mmol) is added. To the resulting solution is added in a single portion NaHMDS (2 M in THF, 1.25 mL, 2.5 mmol). The reaction mixture is stirred at 20° C. for 24 h, then H2O (0.4 mL) is added. The reaction mixture is evaporated and the residue purified by preparative HPLC to provide the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07375227B2
출처 데이터셋	uspto-grants-2008_05
ORD ID	ord-3925a18c660d4ba7bf8c3fa196ebf96e
출처 메모	uspto-grants-2008_05