Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 222372생성일: 2026년 10월 24일
2-Amino-6-methoxybenzothiazole → 1-[(3,4-Dichlorophenyl)methyl]-5-methyl-N-[6-(methyloxy)-1,3-benzothiazol-2-yl]-1H-1,2,3-triazole-4-carboxamide
https://huagongshe.com/ko/reaction/222372
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Amino-6-methoxybenzothiazole | HCID 15630 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | 1-(3,4-dichlorobenzyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid | HCID 55029873 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[(3,4-Dichlorophenyl)methyl]-5-methyl-N-[6-(methyloxy)-1,3-benzothiazol-2-yl]-1H-1,2,3-triazole-4-carboxamide | HCID 25263590 | 10% |
반응 단계
A mixture of 1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (Intermediate 4) (0.1 g, 0.35 mmol), 2-amino-6-methoxybenzothiazole (0.062 g, 0.35 mmol), HATU (0.082 g, 0.45 mmol) and DIPEA (85 μL, 0.45 mmol) in DMF (5 mL) was stirred at 45° C. for 3 days. The solvent was evaporated and the residue was washed with water and extracted with DCM. The organic phase was dried over sodium sulphate, filtered and concentrated in vacuo. The residue was purified by flash chromatography eluting with DCM/MeOH (99/1) to give after trituration in diisopropyl ether, the title compound as a white solid (15 mg, 10%). HRMS calculated for C19H15Cl2N5O2S (M+H)+ 448.0402, found: 448.0403, Rt: 3.31 min. MP: 225° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08207204B2 |
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| 출처 데이터셋 | uspto-grants-2012_06 |
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| ORD ID | ord-e4ca3c39296d4d8b99777e28e5bd05e5 |
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| 출처 메모 | uspto-grants-2012_06 |
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