Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride → 4,4-Dimethyl-6,7-dimethoxy-1-bromomethylisochroman
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride | HCID 6356 | — |
| 반응물 | Acetaldehyde, bromo- | HCID 105131 | — |
| 반응물 | 2-(3,4-Dimethoxyphenyl)-2-methylpropan-1-ol | HCID 13015778 | — |
| 용매 | Nitromethane | HCID 6375 | — |
| 생성물 | 4,4-Dimethyl-6,7-dimethoxy-1-bromomethylisochroman | HCID 20523070 | — |
반응 단계
A 2,2-Dimethyl-2-(3,4-dimethoxyphenyl)ethanol (0.95 g, 0.0045 m) is stirred with 1.07 g (0.0054 m) of the ethyl acetal of bromoacetaldehyde and 0.19 g (0.0014 m) of BF3 .etherate in 25 ml of nitromethane for 15 hours. The mixture is partitioned between methylene chloride and aqueous sodium carbonate. The organic phase is dried over sodium sulfate and concentrated to yield 1.52 g of 4,4-dimethyl-6,7-dimethoxy-1-bromomethylisochroman. The nmr is consistent with the assigned structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04352805 |
| 출처 데이터셋 | uspto-grants-1982_10 |
| ORD ID | ord-3e4b66a471a743eabefd0a20575541a1 |
| 출처 메모 | uspto-grants-1982_10 |