Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → N-(2,6-dichloropyrimidin-4-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 4-Pyrimidinamine, 2,6-dichloro- | HCID 82387 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | N-(2,6-dichloropyrimidin-4-yl)acetamide | HCID 4713752 | 80% |
반응 단계
4-Amino-2,6-dichloropyrimidine (500 mg, 3.05 mmol) was refluxed in acetic anhydride (10 ml) for 3 h. Upon cooling to room temperature, the reaction mixture was cooled in an ice bath and basified to pH 8 with 10% aqueous NaHCO3. The phases were separated, and the aqueous portion was extracted twice with EtOAc. The combined organic portions were dried over Na2SO4, filtered, and concentrated to give an off-white solid (503.7 mg, 2.44 mmol, 80% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07709503B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-c1a94b172384472c8dda843e419df92c |
| 출처 메모 | uspto-grants-2010_05 |