Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N2 acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl)guanine → N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N2 acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl)guanine | HCID 136408872 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine | HCID 136408871 | 44.5% |
반응 단계
To a solution of N2 -acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl)guanine (4.62 g, 9.67 mmol) in 150 ml of methanol plus 40 ml of water was added 20% palladium hydroxide on carbon as a slurry in 10 ml of water. The mixture was hydrogenated on a Parr hydrogenator at 60 psi of hydrogen for 38 hours then filtered through celite and concentrated to a white solid. Recrystallization from methanol/ethyl acetate gave 1.4 g of N2 -acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine, mp 205°-208° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04355032 |
| 출처 데이터셋 | uspto-grants-1982_10 |
| ORD ID | ord-c5cb1a10541d45ec8e6948f10d4220e1 |
| 출처 메모 | uspto-grants-1982_10 |