Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitro-N-methylphthalimide → 5-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitro-N-methylphthalimide | HCID 92321 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 생성물 | 5-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione | HCID 726931 | — |
반응 단계
A solution of give 2-methyl-5-nitro-isoindole-1,3-dione (1.1 g, 5.3 mmol) in ethanol/tetrahydrofuran (1:1, 50 mL) is hydrogenated at 45 psi over Raney nickel catalyst. The reaction mixture is filtered through a pad of diatomaceous earth and concentrated to give 5-amino-2-methyl-isoindole-1,3-dione as a yellow cottony solid (0.85 g, 91%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07713994B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-e3ae9f82d5b44b96b1a0bff5d36b5d7a |
| 출처 메모 | uspto-grants-2010_05 |