Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → HCID 178491933, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 4-Methoxyphenyl isothiocyanate | HCID 75293 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1) | HCID 2723597 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 178491933 | HCID 178491933 | 90% |
반응 단계
A mixture of 17.5 parts of 2-amino-1-phenylethanone hydrochloride, 16.5 parts of 1-isothiocyanato-4-methoxybenzene, 10 parts of sodium hydrogen carbonate and 200 parts of 2-propanol is stirred first for 30 minutes at room temperature and further for 2 hours at reflux temperature. The reaction mixture is poured onto 500 parts of water. The product is filtered off and stirred and refluxed for 1 hour with 240 parts of hydrochloric acid solution 10%. After cooling, the product is filtered off, washed with water and 2-propanol, and dried, yielding 25.3 parts (90%) of 1-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol; mp. 167.4° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04232034 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-76fc430a21894b7891ba1bbb57f43689 |
| 출처 메모 | uspto-grants-1980_11 |