Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Potassium bisulfate | HCID 516920 | — |
| 반응물 | (S)-N-methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide | HCID 11119284 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate | HCID 104275 | — |
반응 단계
Lithium aluminum hydride (2.5 equiv.) is added to a stirred solution of compound (7). Reduction is complete within 15-20 minutes. The mixture is hydrolyzed with a solution of potassium hydrogen sulfate in water. Ether is added and the aqueous phase is separated and extracted. The organic phases are combined, washed with 1N HCl saturated sodium hydrogen carbonate and saturated sodium chloride, and dried with magnesium sulfate. The solvent is evaporated to leave the desired product
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428019 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-c05cdbbfbba14f20a453eb4c70efeaa1 |
| 출처 메모 | uspto-grants-1995_06 |