Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Allylamine → Ethyl 4-(allylamino)-2-phenyl-5-pyrimidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Allylamine | HCID 7853 | — |
| 반응물 | Ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate | HCID 239537 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 4-(allylamino)-2-phenyl-5-pyrimidinecarboxylate | HCID 2767635 | — |
반응 단계
A mixture of 5 g. (0.019 mole) of 4-chloro-2-phenyl-5-pyrimidine carboxylic acid ethyl ester and 2.2 g. (0.038 mole) of allylamine in 150 ml. of ethanol was refluxed 3 hours. At this point, the solution was concentrated to 30 ml. and chilled. A yellow crystalline solid formed and was filtered off to give 4-(2-propenylamino)-2-phenyl-5-pyrimidine carboxylic acid ethyl ester--m.p. 49°-54° C. This compound was used in the next step directly without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04233446 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-f3366defaf7f4263a6a1e45bfe45d77a |
| 출처 메모 | uspto-grants-1980_11 |