Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aniline → Ethyl 4-anilino-2-phenyl-5-pyrimidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | Ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate | HCID 239537 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 4-anilino-2-phenyl-5-pyrimidinecarboxylate | HCID 755251 | — |
반응 단계
A mixture of 10 g. (0.038 mole) of 4-chloro-2-phenyl-5-pyrimidine carboxylic acid ethyl ester and 7.1 g. (0.076 mole) of aniline in 200 ml. of ethanol was refluxed for 3 hours. Upon cooling a yellow solid precipitated from the solution. This was filtered off and rinsed with ethanol to give 4-anilino-2-phenyl-5-pyrimidine carboxylic acid ethyl ester, m.p. 98°-100° C. No further purification was done and the product was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04233446 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-ecf26369a14946b49f993316268478ec |
| 출처 메모 | uspto-grants-1980_11 |