Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Dimethylamino-3'-trifluoromethylacrylophenone → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 반응물 | HCID 178469928 | HCID 178469928 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester | HCID 11198437 | — |
반응 단계
A mixture of 5.0 g. of 3-amino-4-carbethoxypyrazole and 7.84 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone in 25 ml. of glacial acetic acid is refluxed for 6 hours and then evaporated in vacuo to an oil. This oil is treated as described in Example 1, giving the desired product, m.p. 97°-99° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04236005 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-f3e7d24f0dc44fdfbf25a2df623d7cf4 |
| 출처 메모 | uspto-grants-1980_11 |