참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | Ethanesulfonic acid (6-chloro-5-p-tolyl-pyrimidin-4-yl)-amide | HCID 59645274 | — |
| 생성물 | Ethanesulfonic acid [6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-amide | HCID 59645277 | — |
반응 단계
Ethanesulfonic acid (6-chloro-5-p-tolyl-pyrimidin-4-yl)-amide (363 mg) was added to a solution of potassium tert.-butoxide (427 mg) in ethylene glycol (7 ml) and stirred at 100° C. for 7 days. The reaction mixture was then poured onto ice/water and extracted with ethyl acetate. The crude product was purified by chromatography over silicagel with DCM/MeOH=9/1 to give ethanesulfonic acid [6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-amide (310 mg) as a white powder. LC-MS: tR: 3.47, [M+H]+: 338.13.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07323465B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_01 |
|---|
| ORD ID | ord-1eec02ef45494ea5958f5f53f6737d22 |
|---|
| 출처 메모 | uspto-grants-2008_01 |
|---|
