참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Acetic acid, 2-chloro-2,2-difluoro-, ethyl ester | HCID 67843 | — |
| 반응물 | tert-Butyl 5-hydroxy-1,3-dihydro-2H-isoindole-2-carboxylate | HCID 18630963 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Difluoromethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester | HCID 57753212 | 40% |
반응 단계
A mixture containing 0.68 mmol 5-Hydroxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (CAS: 226070-47-9), 0.68 mmol potassium carbonate and 0.68 mmol ethyl chlorodifluoroacetate in 1.5 ml DMF was stirred overnight at 65° C. The mixture was then partitioned between ethyl acetate and water and the organic phase was then separated, dried over sodium sulfate, and concentrated in vacuo. The residue was purified by chromatography on silica gel (eluant: n-heptane/ethylacetate) to afford the title compound as a white solid (40% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07557114B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-7eeace9b5415458084a6e8d730a81053 |
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| 출처 메모 | uspto-grants-2009_07 |
|---|
