Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Phenylpiperidine-4-carboxamide monohydrochloride → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Phenylpiperidine-4-carboxamide monohydrochloride | HCID 3017129 | — |
| 반응물 | 2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide | HCID 53709262 | — |
| 생성물 | 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide | HCID 53969650 | — |
반응 단계
Prepare according to the method of example 57.8 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide (5 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (7.5 mmol, 1.5 eq.). Chromatograph on silica gel to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05661160 |
| 출처 데이터셋 | uspto-grants-1997_08 |
| ORD ID | ord-a56760b756d5462cbbdbadc5176186c2 |
| 출처 메모 | uspto-grants-1997_08 |