Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → HCID 60204465, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(2-Aminoethyl)-5,5-dimethylimidazolidine-2,4-dione | HCID 57428804 | — |
| 반응물 | 2-Chloro-4-(5-iodothiophen-2-yl)pyrimidine | HCID 57428831 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | HCID 60204465 | HCID 60204465 | — |
반응 단계
A solution of 205 mg (0.64 mmol) of 2-chloro-4-(5-iodothiophen-2-yl)pyrimidine, 186 mg (1.1 mmol) of 1-(2-aminoethyl)-5,5-dimethylimidazolidine-2,4-dione and 0.15 mL (1.1 mmol) of triethylamine in 5 mL of iPrOH was heated in a microwave to 180° C. for 10 min then concentrated in vacuo. The crude solid product was purified by flash chromatography eluting with a linear gradient of 40% EtOAc in hexane to 100% EtOAc to deliver the title compound. MS (M+H)+ 458.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07858785B2 |
| 출처 데이터셋 | uspto-grants-2010_12 |
| ORD ID | ord-f4d4c28f336e4501868ccbe598fdbe46 |
| 출처 메모 | uspto-grants-2010_12 |