Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl (ethoxymethylene)malonate → Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 반응물 | 2-Amino-6-methylpyridine | HCID 15765 | — |
| 생성물 | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | 84.7% |
반응 단계
20 g (92.5 mmol) of 2-ethoxymethylene-malonic acid diethyl ester and 10 g (92.5 mmol) of 2-amino-6-methylpyridine were heated neat at 110° C. for 2 h. The reaction was allowed to cool to room temperature and the product was recrystallized from dichloromethane and hexane to afford 21.8 g of 2-[(6-Methyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557213B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-6679bb50a1b64b42a9bc552543a97405 |
| 출처 메모 | uspto-grants-2009_07 |