Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonyl chloride → 3,4,5-Trimethoxybenzyl Mesylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 3,4,5-Trimethoxybenzyl alcohol | HCID 77449 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3,4,5-Trimethoxybenzyl Mesylate | HCID 18464591 | — |
반응 단계
Combine 3,4,5-trimethoxy-benzyl alcohol (9.0 g, 45.4 mmol), diisopropylethylamine (12.9 g, 100 mmol), and acetonitrile (60 mL). Cool in an ice bath. Add methanesulfonyl chloride (6.76 , 49.0 mmol). After 2 hours, partition the reaction mixture between water and ethyl acetate. Separate the layers and extract the organic layer with 1 M hydrochloric acid solution and them a saturated solution of sodium bicarbonate. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06329392B1 |
| 출처 데이터셋 | uspto-grants-2001_12 |
| ORD ID | ord-87018fd455e044e9a2f30a01c3ae272a |
| 출처 메모 | uspto-grants-2001_12 |