Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 1-(triisopropylsilyl)-1H-indol-6-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Triisopropylsilyl chloride | HCID 139400 | — |
| 반응물 | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(triisopropylsilyl)-1H-indol-6-ol | HCID 67226331 | — |
반응 단계
6-Benzyloxy-indole (1.0 g) was treated with NaH (135 mg) and triisopropylsilyl chloride (1.0 g) in tetrahydrofuran for 1 hour, purified by flash chromatography (98/2 ethyl acetate/hexanes), then debenzylated in ethanol (35 mL) using Pearlman's catalyst (0.19 g) and a hydrogen balloon.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09125913B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-33b5daf262f4444e9b85a3a33cd8a8f2 |
| 출처 메모 | uspto-grants-2015_09 |