Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → tert-Butyl 4-(2-((methanesulfonyl)oxy)ethyl)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine | HCID 854140 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | tert-Butyl 4-(2-((methanesulfonyl)oxy)ethyl)piperidine-1-carboxylate | HCID 15229596 | — |
반응 단계
A solution of 4-(2-hydroxyethyl)-piperidine-1-carboxylic acid tert-butyl ester (Aldrich, 0.50 g, 2.2 mmol), triethylamine (0.91 mL, 6.5 mmol), and methanesulfonyl chloride (0.25 mL, 3.3 mmol) in 10 mL THF were processed as described in Example 1C to give the crude title compound which was used directly in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560481B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-cafa41c87a464f51bd663e7e52e25780 |
| 출처 메모 | uspto-grants-2009_07 |