참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | 1-Chloro-4-phenylphthalazine | HCID 272109 | — |
| 반응물 | 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyridin-2-amine | HCID 66735161 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Sodium Carbonate | HCID 10340 | — |
| 생성물 | HCID 57756271 | HCID 57756271 | — |
반응 단계
To 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyridin-2-amine (0.070 g, 0.24 mmol) and 1-chloro-4-phenylphthalazine (0.048 g, 0.20 mmol) was added tBuOH (1.0 mL). The resulting mixture was heated at 100° C. in a sealed tube for 16 hours. The reaction was diluted with diethyl ether and saturated sodium carbonate and vigorously shaken. The resulting solids were filtered and washed with water, diethyl ether and air dried to yield N-(4-(3-(2-(methylamino)pyridin4-yl)pyridin-2-yloxy)phenyl)-4-phenylphthalazin-1-amine as an off-white solid. MS m/z=497 [M+H]+. Calc'd for C31H24N6O: 496.58.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07560551B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-11513d24343d495cade845c8575d7159 |
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| 출처 메모 | uspto-grants-2009_07 |
|---|
