참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 4-((4-Phenylphthalazin-1-yl)amino)phenol | HCID 2869168 | — |
| 반응물 | 3-Bromo-4-chloropyridine hydrochloride | HCID 46941422 | — |
| 생성물 | N-(4-(3-bromopyridin-4-yloxy)phenyl)-4-phenylphthalazin-1-amine | HCID 66731439 | — |
반응 단계
A resealable reaction tube was charged with cesium carbonate (0.873 g, 0.268 mmol), 3-bromo4-chloropyridine hydrochloride (0.205 g, 0.894 mmol) and 4-(4-phenylphthalazin-1-ylamino)phenol (0.280 g, 0.894 mmol) and purged with nitrogen for several minutes. 1.8 mL of DMSO was added, the tube was sealed, and the reaction mixture was heated to 130° C. for 3 h. Upon cooling the mixture was diluted with EtOAc and washed with water. The aqueous portion was extracted with EtOAc, and the combined organic portions were dried with MgSO4 and concentrated. N-(4-(3-bromopyridin4-yloxy)phenyl)-4-phenylphthalazin-1-amine was isolated as an orange solid. MS m/z=470 [M+H]+. Calc'd for C25H17BrN4O: 469.33.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07560551B2 |
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| 출처 데이터셋 | uspto-grants-2009_07 |
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| ORD ID | ord-701778624983464196d5468755766ebc |
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| 출처 메모 | uspto-grants-2009_07 |
|---|
