Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 3,4-Dimethylbiphenyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Chloro-o-xylene | HCID 32886 | — |
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 촉매 | Sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxybiphenyl-3-sulfonate | HCID 23677046 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3,4-Dimethylbiphenyl | HCID 20492 | 99% |
반응 단계
The general procedure described in Example 3 was used with 3,4-dimethyl-chlorobenzene (0.140 mL, 1.00 mmol), phenylboronic acid (157 mg, 1.20 mmol), Pd(OAc)2 (4.5 mg, 0.020 mmol, 2 mol %), sodium 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl-3′-sulfonate (20.0 mg, 0.040 mmol, 4 mol %), K2CO3 (276 mg, 2.00 mmol), water (1.0 mL), 10 h, room temperature. The product was isolated as a colorless oil (151 mg, 99%). 1H NMR (400 MHz, CDCl3) δ: 7.82 (d, 2H, J=7.6 Hz), 6.81-7.55 (m, 6H), 2.24 (s, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560596B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-0fa6bfda377847089237a7f9d9a9b847 |
| 출처 메모 | uspto-grants-2009_07 |